FAQ: What is translational research?

What is considered translational research?

Translational research includes two areas of translation. One is the process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans.

What is an example of translational research?

One prime example of translational research in human disease is the study of cancer therapy. Extensive cooperation between basic researchers, clinicians, and industry has generated numerous new targeted compounds with enhanced efficacy and decreased toxicity.

What are the 3 types of translational research?

There are generally two categories of translational research: T1 (basic to clinical) and T2 (clinical to population); however T1, T2, and T3 are often used to represent transitions between to patient-oriented, patient oriented to population-based, and basic to population-based research [2], respectively; a third usage

What is the methodology of translational research?

Translational research is a bidirectional process that involves multidisciplinary integration among basic, clinical, practice, population, and policy-based research. The goal of translational research is to speed up scientific discovery into patient and community benefit.

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What is the goal of translational research?

Translational research seeks to produce more meaningful, applicable results that directly benefit human health. The goal of translational research is to translate (move) basic science discoveries more quickly and efficiently into practice.

Why translational research is important?

The steps in translational research are designed to ensure that the discoveries that advance into human trials have the highest possible chance of success in terms of both safety and efficacy. Weeding out failures earlier in the process can significantly decrease the overall cost of developing new products.

What is the difference between clinical and translational research?

Clinical research is the study of human subjects and involves testing new methods of diagnosis, prevention and the treatment of illness. Translational research acts as a bridge between science and practice. It links laboratory science with patients and findings with the needs of the community.

What is the meaning of translational?

trans·la·tion·al

adj. 1. Of or relating to translation. 2. In science, of or relating to the application of basic or theoretical discoveries to the development of practical applications: translational research.

What does translational medicine mean?

Translational medicine, also called translational medical science, preclinical research, evidence-based research, or disease-targeted research, area of research that aims to improve human health and longevity by determining the relevance to human disease of novel discoveries in the biological sciences.

What does bench to bedside mean?

Listen to pronunciation. (bench BED-side) A term used to describe the process by which the results of research done in the laboratory are directly used to develop new ways to treat patients.

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What is T2 translational research?

For the purposes of this FOA, T2 translational research on aging is defined as research to gather information needed to develop or evaluate methods of translating results from clinical studies into everyday clinical practice and health decision making (e.g., adapting an efficacious intervention for application in

What is T3 translational research?

With T3 translational research, investigators explore ways of applying recommendations or guidelines in general practice. T3 research yields knowledge about how interventions work in real-world settings.

How is EBP defined as translational research?

EBP is the actual application of evidence in practice (the “doing of” EBP), whereas translation science is the study of implementation interventions, factors, and contextual variables that effect knowledge uptake and use in practices and communities.

How is data collected in translational research?

Translational research involves many scientists and clinicians compiling multiple data types and sources. These may include deidentified patient data, whole genome or exome sequences, specific tumor sequences, specimen records from patient blood draws, biopsies, and more.

What is a translational science model?

The Translational Science Benefits Model (TSBM) is a framework designed to support institutional assessment of clinical and translational research outcomes to measure clinical and community health impacts beyond bibliometric measures.

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